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Santa Cruz [S] (or Santa Cruz de la Sierra [S]) is the most populous city and heart of the second most populous metropolitan area in Bolivia, and is the capital of the department of Santa Cruz. It is considered the most economically prosperous city in the country.

In contrast to La Paz [S] and the other major Bolivian cities located high in the Andes, Santa Cruz [S] lies at an altitude of 416 meters, and its climate is distinctly tropical.
If you arrive during carnival it is almost impossible to change money as everything except markets, restaurants and internet cafes are closed. Traders will accept U.S. dollars but at half the going rate. Also be prepared to be pelted with ink filled water balloons, soaked with water bombs and covered in string spray. Wear clothes you don`t mind having permanently stained.
The bus station listed in the Santa Cruz [S] web site is no longer in use. The new one (half completed) is a 15 Bs taxi fare from the centre of town. Of the three hostels listed with 24 hour reception, the only one that does is on tres pasos, a couple of km out of the city center.
The "death train" (so named because of its history in transporting Yellow Fever victims) runs on bumpy tracks from Quijarro, close to Corumbá on the Brazilian side. There is a variety of different trains offering different classes and prices. The journey takes 16-22 hours. The most comfortable option, with cama seats, is the "Ferrobus" (Tues, Thurs, Sat) which at time of writing (April 2010) cost 250Bs per person. Contrary to what is written in many guidebooks, tickets can be purchased days in advance at the station (Terminal Bimodal). Biting insects are plentiful, so get repellent before you go.
The railway between Santa Cruz [S] and Quijarro is operated by Ferroviaria Oriental S.A. [1].
From Corumbá the bus-ride to Sao Paulo takes about 24 hours more.
Viru Viru International Airport [S] (IATA: VVI, ICAO: SLVR) is Bolivia's largest and most modern airport, and a hub for BOA as well as the popular but expensive AeroSur. They offer direct flights from Miami to Santa Cruz [S] a few times a week. They also offer flights from Madrid to Santa Cruz.
El Trompillo Airport [S] (IATA: SRZ, ICAO: SLET) is the city's military airport, and is used by TAM airlines for internal flights (to Cochabamba [S] [M] and Sucre [M], for example). Trompillo is closer to the city center, and is thus a cheaper taxi ride.
Major airlines have daily flights to Santa Cruz de la Sierra [S], mainly from La Paz [S] (about 4 flights per day: early in the morning, in the afternoon, early in the evening and late in the night). From Cochabamba [S] [M] (about 2 flights per day). Flights to international cities is also daily, (Sao Paulo, Brasil - Buenos Aires, Argentina - Lima, Peru - etc. there are daily flights). American Airlines has daily service to and from Miami.
About Bolivian airlines and flying within Bolivia: Bolivia#Get_around
There are many bus companies from another cities, like Cochabamba [S] [M], La Paz [S], Sucre [M], Trinidad, that go to Santa Cruz de la Sierra [S]. You can arrive from La Paz in about 18 hours, and it takes about 10 hours from Cochabamba. The Bolivia Vice-Ministry of Tourisum has a bus schedules on their website: [2]. Look under Destinations and the area you are interested in traveling.
Micro 17 circulates the first ring. To get to the center from Parque Urbano take Micro 69 or 100.
Shared Taxis circulate the rings as well. Look for the signs on the roof. Faster than Micros.
Fare for both is 1.50 Bs.
In Santa Cruz [S] you can book some great excursions, like a trekking in Park Amboro [S], Noel Kempff [S], a river boat trip in the Amazon [S] region, cultural excursions to the Jesuit Missions [S] etc.
A good and reliable tour agency is Dutch owned Ruta Verde [S] [3]. They are located 3 blocks from the plaza, Calle 21 de Mayo 332.
Santa Cruz [S] hosts one of the most famous soccer academy in the world. "Academia de Futbol Tahuichi Aguilera". Their unique and original way of training young soccer players to become professionals in the future. They train in rivers and ran through mountains of sand. Young players from all over the world come to this academy to experience its training method.
There are several good restaurants in the north of the city.
Avenida Busch is a good place to start a longer night. There are several Pubs there and you are still close to the center. If you want some classic italian cappuccino, espresso, frappuccino or croissant there is the "Espresso del Oriente" Cafe-Pub on Bolivar Street 272 located two and a half blocks far from the main Plaza. A during-the-week runner is the Irish Pub at the main Plaza.
Equipetrol is the party place, try any club or disco there.
Av. Monseñor Rivero is a popular boulevard if you want a coffee or a drink.
There are some hotels close to the bus terminal which is a bit further away from the center. A large Bolivia Hotels and Hostels Directory is www.boliviahostels.com [5], they offer accommodation all over the country and you can make reservations for free.
If you have a layover in Viru Viru, you can rent a room in the airport if you want to take a nap or if you get in late and have an early flight the next morning. It's called en-kma and is a small dorm style room with wi-fi, bed, mini-fridge, tv, and air conditioning. Its 10 US dollars/hour but if you stay longer, they will give you a discount. Its suprisingly very clean and more comfortable than expected.
United States (Consular Agency), Avenida Roque Aguilera #146 (3er Anillo), ☎ +591-3-351-3477 (fax: +591-3-351-3478), [9].
A good internet cafe is at the corner of Avenida Cañoto and Buenos Aires. Its hyperfast, air conditioned and cheap.
Cheap call centers can be found everywhere in the city. Tel Viva use communication over the internet and carge therefore only 0.50 bolivianos/minute.
There is a bus to Cochabamba [S] [M], takes 10 hours, for 30 or 40 Bolivianos.
Shared Taxis to Samaipata [S] leave from :
There are buses to Asunción, Paraguay. The trip takes around 23hrs. Daily departures in the evening from the Nuevo Terminal. Around $40-50 for a bus including food (bargain as much as you can). The travel agencies will not hesitate to lie to sell you a ticket and an old seat will become a "cama". Expect 15 to 18 police checks on the way, especially in Paraguay. The road throught the Chaco is quite good, but the trip is very long.
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